Sale!

Kisspeptin

Price range: $40.00 through $55.00

A naturally occurring neuropeptide extensively studied in laboratory settings for its pivotal orchestration of the HPG axis through direct stimulation of GnRH neurons and downstream gonadotropin release. Kisspeptin continues to attract significant attention in controlled research models exploring reproductive signaling, metabolic interplay, and behavioral modulation, reflecting reassuring progress from recent studies into its precise and adaptive influence on physiological homeostasis and resilience.

Guaranteed Safe Checkout

🔒

Secure & Discreet Shipping Your order is packed carefully with privacy in mind.

🚚

Same-Day Shipping Orders placed before 2PM are processed the same business day.

🧪

COA-Backed Products Every qualifying product is backed by batch-level documentation.

View COA Vault →

Laboratory Handling Directions

Store at controlled room temperature (15–25°C / 59–77°F)
Protect from light and moisture during storage
Use aseptic technique when handling compound
Reconstitute with sterile or bacteriostatic water as appropriate
Once reconstituted, refrigerate at 2–8°C (36–46°F)
Document all handling procedures per laboratory protocols

Critical Compliance Notice

FOR RESEARCH USE ONLY. This product is sold strictly for in-vitro laboratory research, educational purposes, and scientific investigation. It is NOT intended for human or veterinary use. By purchasing this product, the buyer confirms they are a qualified researcher and assumes full responsibility for ensuring compliance with all applicable regulations.

Mechanism of Action

Kisspeptin (primarily kisspeptin-54 and its shorter forms like kisspeptin-10) is a neuropeptide that binds to the kisspeptin receptor (KISS1R/GPR54), a G protein-coupled receptor predominantly coupled to Gq/11 proteins. This activates phospholipase C, leading to IP3-mediated intracellular calcium release, DAG production, PKC activation, and downstream signaling via MAPK/ERK pathways, PI3K/Akt, and in some cases cAMP elevation through Gs crosstalk. These cascades stimulate GnRH neuron depolarization and pulsatile GnRH secretion from the hypothalamus, thereby driving gonadotropin (LH and FSH) release from the pituitary and regulating the hypothalamic-pituitary-gonadal (HPG) axis. Recent laboratory investigations continue to elucidate its pleiotropic effects, including modulation of sexual behavior circuits, metabolic homeostasis, anti-inflammatory actions, cardiovascular tone regulation, and potential neuroprotective influences, with reassuring evidence highlighting its role in synchronizing neuronal networks (e.g., via glutamate-AMPA in arcuate kisspeptin neurons) and supporting adaptive reproductive and physiological responses in diverse models.

Research Applications

HPG axis regulation and pulsatile GnRH/LH/FSH secretion studies
Puberty onset and reproductive maturation pathway investigations
Hypogonadotropic hypogonadism and infertility mechanism analysis
Metabolic-reproductive integration and energy balance research
Sexual behavior and motivation modulation in neural circuits Polycystic ovary syndrome (PCOS) and functional hypothalamic amenorrhea models
Neuroendocrine responses in aging, stress, or post-viral conditions evaluation