VIP

Laboratory Handling Directions

• Store at controlled room temperature (15–25°C / 59–77°F)
• Protect from light and moisture during storage
• Use aseptic technique when handling compound
• Reconstitute with sterile or bacteriostatic water as appropriate
• Once reconstituted, refrigerate at 2–8°C (36–46°F)
• Document all handling procedures per laboratory protocols
  

Mechanism of Action

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide that exerts its effects primarily through binding to VPAC1 and VPAC2 receptors (class II G protein-coupled receptors), stimulating adenylate cyclase to increase intracellular cAMP levels. This leads to downstream modulation of pathways such as p38 MAPK, promoting processes like epithelial secretion, vasodilation, smooth muscle relaxation, and immune regulation. Laboratory studies highlight its role in suppressing pro-inflammatory cytokines, enhancing regulatory T-cell responses, influencing epithelial differentiation toward a secretory phenotype, and supporting neuroprotection and metabolic homeostasis, with recent investigations demonstrating sustained effects on cellular signaling and tissue repair mechanisms.

Research Applications

• Immunomodulation and anti-inflammatory pathway studies

• Gastrointestinal epithelial secretion and differentiation research

• Neuroprotective and circadian rhythm regulation investigations

• Metabolic homeostasis and glucose-dependent insulin secretion analysis

• Intestinal injury repair and radiation protection models

• Autoimmune and inflammatory disease modulation evaluation

Scientific References

• Iwasaki M et al. F1000Res. 2019;8:F1000 Faculty Rev-1629.

• Hou X et al. Front Endocrinol (Lausanne). 2022;13:984198.

•  Agibalova T et al Stem Cell Res Ther. 2024;15(1):348.

• Baccari MC et al. Int J Mol Sci. 2025;26(24):11797.